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What are the effects of unsweetened coffee on the brain and body, according to science?

articleUseronApril 22, 2026

A study published by Johns Hopkins University analyzed what happens to the body when you drink coffee without sugar.

A Johns Hopkins University study, published in Nature Neuroscience, analyzed how black coffee consumption impacts the body. Researchers found signals linking this beverage to cellular protection mechanisms and changes in neuronal activity. The evidence suggests effects beyond the simple stimulation provided by caffeine.

What happens to the body when you drink coffee without sugar?

Scientists detected specific effects in the hippocampus, the brain region associated with memory and learning. According to the study, regular consumption of unsweetened coffee enhances connectivity between neurons and can improve cognitive ability, provided it is consumed in moderation. These changes would improve attention and memory consolidation.

Metabolically, the study points to two mechanisms by which unsweetened coffee can help control weight: increased thermogenesis and a higher basal metabolic rate. By increasing energy expenditure and accelerating nutrient processing, coffee may contribute to weight loss strategies when combined with diet and exercise.

The benefits and risks of coffee according to experts

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